Medication-related problems (MRPs) place a substantial burden on the healthcare system, contributing to hospital admissions and significant healthcare costs. Quality prescribing indicators, rules, and criteria serve to educate prescribers about high risk MRPs and to monitor prescribing behaviours. This study aims to summarise existing indicators, rules, and criteria for quality prescribing of medicines in primary care. Four databases (OVID-MEDLINE, OVID-Embase, EBSCOhost-PsycINFO, and ProQuest-International Pharmaceutical Abstracts) were searched for studies published between 2000 and 2025, across three intersecting areas: (i) general or family practice setting, (ii) prescriptions/medicines/medication/drugs, and (iii) quality indicators/rules/best practice. AI software ASReview® assisted by prioritising titles and abstracts for screening. To be included, the manuscript had to describe the development of novel rules relevant to primary care settings, and be specific to medications or conditions and not address the general writing of a prescription. Of the 41,962 papers identified, 1,859 were title and abstract screened by the review team before reaching our threshold of 420 consecutively irrelevant papers. Full-text review of 133 papers, including 11 reviews of quality prescribing indicators, resulted in 1,486 prescribing rules, covering 54 therapeutic areas, being extracted. Most studies focused on older patients, only three specified they were applicable to a general adult population, and six focused on specific medical conditions. Therapeutic areas with the most rules were psychoanaleptics, psycholeptics, and antithrombotic agents. This review highlights the breadth of prescribing rules, limited methodological diversity, and the need for future research to optimise emerging therapies.