Recent innovations in genetic technologies and epigenetic analysis have reshaped personalized medicine (Wu & Li, 2022). Additionally, employing encryption and data management mechanisms—such as hash/token frameworks integrated with blockchain-based approaches—offers enhanced data security, transparency, and efficient governance in the digital age (Chen et al., 2022). This paper introduces a novel perspective on combining DNA data and epigenetic profiles with hash/token technology , underscored by blockchain solutions to manage large-scale storage, authentication, and transactions of biological data. The proposed ecosystem is implemented via the Internet of Personal Health Things (IoPHT), augmented by AI-driven analytics, quantum-safe cryptography, and stringent regulatory compliance (HIPAA, MHRA, ISO, etc.). By elucidating the theoretical basis of DNA tokenization, presenting a methodological roadmap for real-world validations, and highlighting how this synergy could transform preventive healthcare and personalized treatment, the paper aspires to lay the groundwork for a fully regulated marketplace in genomic–epigenetic data exchange. Addressing pressing issues of data integrity, consent, and multidisciplinary collaboration, our framework paves the way for a new personalized healthcare industry , empowering both patients and key stakeholders (Brown et al., 2023).