Modern systems face increasingly sophisticated threats, driving the need for detection frameworks capable of identifying complex behavioral anomalies. Through integrating neural architectures with flowgraph analysis, a versatile framework was developed to classify malicious activities with high accuracy and adaptability. Temporal dependencies and structural patterns in system behavior are dynamically analyzed to differentiate between benign and malicious operations, even in the presence of obfuscation and polymorphic strategies. Experimental results demonstrated consistent outperformance over traditional methods, particularly in terms of reducing false positive rates while maintaining robust classification precision. The modular design facilitates deployment across a variety of operational environments, from distributed systems to real-time detection scenarios. Scalability testing revealed that detection performance remained stable even with increasing data complexity, affirming its suitability for large-scale applications. Adversarial testing highlighted the framework's resilience against perturbation attacks, ensuring reliable performance under evolving threat landscapes. Efficiency metrics, including energy consumption and latency, further validated its practicality for enterpriselevel integration. Adaptability to diverse ransomware families, such as LockBit, Hive, and Conti, was demonstrated through thorough experiments, illustrating its versatility in addressing different attack vectors. Challenges posed by imbalanced datasets were effectively mitigated, showcasing the system's capacity to maintain accuracy in skewed conditions. Real-world applications extend to securing critical infrastructure, IoT ecosystems, and cloud platforms, where rapid and accurate threat detection is crucial. Neural-Mimetic Flowgraph Analysis emerges as a substantial advancement in cybersecurity, offering a robust solution to evolving digital threats.