CO2 injection into Permian Basin reservoirs faces challenges due to low-permeability rocks and the complex interactions between CO2, brine, and rock. This paper examines the impact of relative permeability on carbon storage, offering practical insights into storage capacity, pore structure, distribution, and capillary pressure. It compares reactive transport simulation using the geochemical model, aided by PetraSim/Toughreact software, with laboratory experimental data to validate the geochemical reactions, providing practical solutions for carbon storage in reservoirs. This research presents a comprehensive approach that integrates geochemistry and petrophysical properties during core flooding of Permian core samples.Ā The methodology encompasses a comprehensive petrophysical characterization and analytical chemistry of the rock fabric, utilizing XRD and SEM. Coreflooding experiments were conducted to observe dispersion and chemical changes, with in-situ density variation monitoring using industrial and micro-CT scanners. Geochemical data for model input were obtained through Inductively Coupled Plasma (ICP) analysis. Thin-section measurements enabled a detailed assessment of mineralogy, pore structures, and changes in geochemistry resulting from CO2 interactions. A 30-day CO2 storage experiment revealed evidence of mineral dissolution, supported by increased concentrations of Ca, Mg, and Mn in post brine samples. Micro-CT imaging and nuclear magnetic resonance (NMR) confirmed changes in pore geometry and validated mineralization, precipitation, and dissolution (MPD) effects. Relative permeability measurements captured changes due to CO2 flow and residual trapping.Ā This study provides new insights into CO2-brine-rock interactions across various timescales, thereby enhancing predictive capabilities for long-term storage. Reactive transport modeling aligned with laboratory studies, elucidating long-term storage dynamics, including porosity, permeability, mineralization, precipitation and dissolution (MPD), and reaction changes using PetraSim. In this research, the additional use of nuclear magnetic resonance (NMR) validated the pore structure of the core sample, both before and after carbon storage, in terms of MPD and geochemistry. Using geochemical reactive transport simulators such as Toughreact, we created a geochemical model by combining laboratory and simulation studies. Our findings aim to enhance the future monitoring and management of CO2 sequestration systems, thereby contributing to climate change mitigation efforts in the Permian Basin.