We herein performed a series of brain/core temperature discordance studies in setting of brain excitation and depression to assess whether noninvasive temperature measurement at highly transmissive eyelid skin overlying newly discovered brain-eyelid thermal tunnel (BTT°) is specific for brain as opposed to core temperature (Core°). BTT°-Core° was determined during hypothermic cardiopulmonary bypass (CPB), seizures induced during electroconvulsive therapy (ECT), pharmacologic depression by sedation and anesthesia, sleep, stroke, brain trauma, and exercise in hot environmental chamber. During brain-core decoupling BTT° follows brain neuronal activity. BTT°-Core° varied dramatically due to extreme changes during CPB. During ECT, BTT° ipsilateral to induced seizure increased from 36.38±0.4°C pre-seizure to 36.69°±0.3°C at two minute post-seizure (p<0.001 by paired t-test); Core° remained within 0.01°C of baseline (p=0.2). These changes were accompanied by BTT°-Core° discordance ranging from-0.1°C pre-seizure to +0.31°C post-seizure. Alternatively, during brain neuronal depression, BTT° ipsilateral to evolving ischemic stroke and Core° were 35.37±0.2°C and 36.00±0.09°C, respectively, with p<0.0001 for BTT°-Core° of 0.63±0.13°C. These findings document specificity of BTT transmission for brain thermal energy and illustrate potential BTT° usefulness in myriad clinical and investigative settings.