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Studies on the biological functions of human POTEE protein in cancer cells using a recombinant approach
  • +3
  • * Anjali,
  • Km Archana,
  • Arun Kumar,
  • Shriyanshi Mishra,
  • Durga Prasad Mishra,
  • Raj Kamal Tripathi
* Anjali
Academy of Scientific and Innovative Research
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Km Archana
Academy of Scientific and Innovative Research
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Arun Kumar
Academy of Scientific and Innovative Research
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Shriyanshi Mishra
CSIR-Central Drug Research Institute
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Durga Prasad Mishra
CSIR-Central Drug Research Institute
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Raj Kamal Tripathi
CSIR-Central Drug Research Institute

Corresponding Author:rk_tripathi@cdri.res.in

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Abstract

The 14 paralogs of the POTE gene family are distributed across eight distinct chromosomes in humans. The POTEE (POTE ankyrin domain family member E) has been shown to express in several human malignancies, including colon, prostate, lung, breast, ovarian, and pancreatic cancers. This study aimed to raise POTE2B (isoform 2 of POTEE protein) polyclonal antibodies in BALB/c mice to characterise and investigate the early detection of human POTEE protein in malignant cells. To generate a specific pol