Background: TFE3 rearranged renal cell carcinoma (TFE3 rRCC) is a rare subtype of RCC involving chromosomal breaks and recombination. Because the rarity, clinical factors affecting the metastasis in TFE3 rRCC are insufficient. The purpose of this meta-analysis is to provide further investigation in this regard. Methods: Pubmed, MEDLINE, Web of Science, EMBASE and Cochrane databases were searched for published studies on the clinical features of TFE3 rRCC. Literature published between May 2004 and December 2023 was searched. Results: A total of 11 studies with 192 subjects were included. Pooled data showed that the number of all female patients was higher than that of males, with a combined OR of 2.45 (95% CI = 1.64-3.66). The incidence of distant metastases (OR = 3.08, 95% CI = 1.06-8.93) and peritoneal metastases (OR = 4.74, 95% CI = 1.19-18.87) were comparable between males and females. Adult females had a higher risk of developing metastases than males, with a combined OR of 4.29 (95% CI = 1.38-13.37), whereas there was no gender advantage in children (OR = 0.30, 95% CI = 0.06 -1.53). Furthermore, the forest plot suggested a significant difference in the probability of distant metastases between paediatric and adult patients (OR = 0.03, 95% CI = 0.01 - 0.07). Conclusions: Adult patients are more likely to develop distant metastases than paediatric patients, with adult females being more likely to develop distant metastases comparing to adult males, indicating that intensified follow-up should be performed on this subgroup in patients with TFE3 rRCC.