Background: In humanitarian crises, reliable and accurate information about health, security and humanitarian aid can be a tool for survival. At the same time existing social structures and information systems are often disrupted, leading to uncertainty and challenges in interpreting information including information that may guide individual public health decisions, particularly as part of vaccination programmes. This study aims to systematically explore the existing literature on these dynamics. Methods: A scoping review [(1)](#ref-0001) was conducted using the key themes: misinformation, infodemic, vaccine confidence and trust with relevant synonyms and subheadings included to build the search strategy. Initial searching was conducted through Medline (Ovid), Embase (Ovid), Global Health (Ovid), PsycInfo (Ovid), Web of Science and SCOPUS, and through handsearching reference lists. Articles were screened and data extracted using Covidence software [(2)](#ref-0002). A content analysis was used to elucidate common and overlapping themes [(3)](#ref-0003). Findings: In total, 41 studies from 14 specific country contexts as well as four from regional and global analyses met the inclusion criteria. The themes identified were (1) the drivers of mistrust (2) the complexity of misinformation and vaccine confidence and (3) equity and programming with communities. Conclusion: The scoping review concluded that trust is essential for vaccine confidence in crisis contexts. However, trust is a complex process shaped by various factors including historical injustices, political dynamics, power dynamics and information. The synthesized evidence demonstrates the importance of community-driven interventions, equitable vaccine distribution and culturally sensitive communications strategies. A consistent finding was that critical knowledge gaps remain about the interplay of trust, information and vaccine confidence in crisis settings to support humanitarian response.