Vegetables are essential for human diets, providing crucial nutrients for metabolic reactions, but their production is low in many countries due to soil-borne diseases and other factors. The strategies of microbiome on vegetable disease management, challenges and future perspectives needs attention and awareness creation. Therefore, the objective of this review is reviewing and creating awareness on the Strategies, challenges and future perspectives of microbiome in Vegetable Disease Management. Plant microbiomes, microbial communities associated with plant tissues, can help manage diseases like Fusarium wilt, bacterial wilt, root rot, and others through mechanisms such us production of Enzymes; secretion of extracellular cell wall degrading enzymes, production of Antibiotics and secondary metabolites; rhizosphere colonization, production of Siderophores, HCN and indole acetic acid, production of Antibiotics and metabolites, antibiosis induced systemic resistance, production of endo and exo glucanases and production of antimicrobial activity of organic acids respectively. Environmental and host-related factors, including agricultural practices, temperature, plant species, and developmental stages, influence plant-microbe interactions. Despite their potential, microbiome strategies face challenges and require greater awareness and more research. Future research should focus on understanding these interactions under various conditions and host-specific factors.