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Type of article: review Title: Irisin is a Potential Novel Biomarker and Therapeutic Target Against Kidney Diseases
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  • Xiu Huang,
  • Xiya Ren,
  • Limei Zhao,
  • Yajie Hao,
  • Zhibo Zhao,
  • Fahui Chen,
  • Jinxiu Zhou,
  • Mengqi Bai,
  • Si Chen,
  • Xiaoshuang Zhou
Xiu Huang
Nephrology Department of Shanxi Provincial People’s Hospital
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Xiya Ren
Nephrology Department of Shanxi Provincial People’s Hospital
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Limei Zhao
Nephrology Department of Shanxi Provincial People’s Hospital
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Yajie Hao
Nephrology Department of Shanxi Provincial People’s Hospital
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Zhibo Zhao
Nephrology Department of Shanxi Provincial People’s Hospital
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Fahui Chen
Shanxi University of Chinese Medicine
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Jinxiu Zhou
Nephrology Department of Shanxi Provincial People’s Hospital
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Mengqi Bai
Shanxi University of Chinese Medicine
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Si Chen
Nephrology Department of Shanxi Provincial People’s Hospital
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Xiaoshuang Zhou
Nephrology Department of Shanxi Provincial People’s Hospital

Corresponding Author:xiaoshuangzhou69@163.com

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Abstract

Kidney diseases, characterized by renal dysfunction, are among the leading causes of death worldwide. Preventing and treating kidney diseases is important for reducing their associated morbidity and mortality. Moderate physical exercise has been recognized to be advantageous for kidney health. Irisin is an exercise-induced myokine identified in 2012. It plays an important role in energy and bone metabolism, oxidative stress reduction, anti-inflammatory processes, prevention of cell death, and cardiovascular protection. However, the relationship between irisin and kidney disease has not been fully elucidated. This review explores the role of irisin as a biomarker in the diagnosis of kidney diseases and their associated complications, elucidating the mechanisms through which it participates in various cell death pathways, such as apoptosis, autophagy, pyroptosis and ferroptosis. Furthermore, the levles of irisin secretion are discussed to provide a basis for the preventing and treating kidney diseases, as well as therapeutic guidance for developing new and promising intervention strategies.
29 Oct 2024Submitted to Cell Biochemistry & Function
04 Nov 2024Submission Checks Completed
04 Nov 2024Assigned to Editor
04 Nov 2024Review(s) Completed, Editorial Evaluation Pending
07 Nov 2024Reviewer(s) Assigned