Bone marrow mesenchymal stem cells induced to differentiate into
cardiomyocyte-like cells and their protective effects on the heart
during myocardial infarction
Abstract
With the increasing aging of the population and the increasing number of
patients with cardiovascular diseases, how to improve the damage of
myocardial cells caused by acute myocardial infarction (AMI) and improve
cardiac function after infarction has attracted widespread attention.
Bone marrow mesenchymal stem cells (BMSCs) are easy to obtain and
proliferate, naturally lack MHC class II antigens, and have the function
of promoting angiogenesis. They have become ideal seed cells for
improving the prognosis of myocardial infarction in tissue engineering.
This review mainly summarizes the biological characteristics of BMSCs
and the chemical, physical, co-culture, and gene transfection methods
for inducing BMSCs to differentiate into cardiomyocyte-like cells in
vitro, and discusses the protective effects of BMSCs and their exosomes
on the heart in myocardial infarction.
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