Background: The crosstalk between the pulmonary artery smooth muscle cell(PASMC) and fibroblast had influenced the vascular inflammation, the role of NDRG1 in vascular inflammation still need to be explored further.Methods:CCK8 assay was used to investigate the effect of NDRG1 overexpression on the proliferative capacity of PASMCs, quantitative reverse transcription PCR(rt-qPCR) was used to investigate the role of NDRG1 overexpression on the expression of inflammatory factors in PASMCs, and EDU assay and scratch assay were used to investigate the effect of PASMCs with overexpression of NDRG1 on the proliferative and migratory capacity of fibroblasts.Results:CCK8 assay of PASMCs overexpressing NDRG1 showed a significant increase in proliferative capacity compared to controls, and PASMCs with knockdown of NDRG1 showed a significant decrease in proliferative capacity. In addition, rt-qPCR assay suggested that the expression of inflammatory factors IL-6 and TNF was significantly elevated in PASMCs overexpressing NDRG1( P<0.05). Compared with control fibroblasts, the expression of TNF-α and SMA in fibroblasts cocultured with overexpressing NDRG1 were significantly elevated( P<0.05). Besides, the expression of IL-6, IL-10 were not significantly( P>0.05), and the proliferation and migration abilities were significantly increased( P<0.05).Conclusions:NDRG1 might had played important roles in the vascular inflammation.