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Sorafenib Combined with DOAP Regimen for the Treatment of BRAF V600E-Negative Langerhans Cell Sarcoma: A three-year follow-up result
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  • Jing Zhang,
  • Xueqin Li,
  • Jingping Zhang,
  • LiangLiang Ma,
  • Shanglun Yang,
  • Qianya Peng,
  • Xiaoqing Chen,
  • Wei Li,
  • Zhaodong Shen,
  • Xiaoyan Guo,
  • Yongqian Jia
Jing Zhang
Meishan city People 's Hospital
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Xueqin Li
Meishan city People 's Hospital
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Jingping Zhang
Meishan city People 's Hospital
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LiangLiang Ma
Meishan city People 's Hospital
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Shanglun Yang
Meishan city People 's Hospital
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Qianya Peng
Meishan city People 's Hospital
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Xiaoqing Chen
Meishan city People 's Hospital
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Wei Li
Meishan city People 's Hospital
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Zhaodong Shen
Meishan city People 's Hospital
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Xiaoyan Guo
Meishan city People 's Hospital
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Yongqian Jia
Sichuan University West China Hospital Department of Hematology

Corresponding Author:jia_yq@scu.edu.cn

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Abstract

Objective: The purpose of this study is to investigate the clinical efficacy of the combination therapy of sorafenib and DOAP (doxorubicin, vincristine, cytarabine, and prednisone) in the treatment of a case of Langerhans cell sarcoma (LCS) negative for BRAF V600E mutation. Furthermore, we aim to retrospectively analyze the clinical characteristics, diagnosis, treatment, and prognosis of LCS. Methods: We conducted a retrospective analysis of the clinical data, pathological examination, and treatment of a patient with LCS, along with a review of relevant literature both domestic and international. Results: After four cycles of sorafenib combined with DOAP chemotherapy, the patient underwent sequential local radiotherapy, resulting in complete remission of the disease. The treatment-related side effects were manageable, and the patient tolerated the treatment well. The patient has survived for 40 months. Conclusion: LCS is a highly rare and aggressive malignancy that can involve various organs throughout the body. It presents with complex and diverse clinical manifestations, progresses rapidly, and has a poor prognosis. Treatment options include surgery, radiotherapy, chemotherapy, targeted therapy, and hematopoietic stem cell transplantation. However, there is currently no universally recognized optimal treatment protocol, and personalized treatment is necessary. Targeted therapy offers new hope for LCS patients.
18 Aug 2024Submitted to Cancer Reports
28 Aug 2024Submission Checks Completed
28 Aug 2024Assigned to Editor
28 Aug 2024Review(s) Completed, Editorial Evaluation Pending
13 Sep 2024Reviewer(s) Assigned