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Nicotinic Acetylcholine Receptor Pathways in Cancer: From Psychiatric Clues to Therapeutic Opportunities
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  • Mohammad Hossein Azadi,
  • Pouya Pazooki,
  • Soheila Ajdary,
  • Hamed Shafaroodi
Mohammad Hossein Azadi
Kharazmi University Faculty of Biological Sciences
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Pouya Pazooki
University of Calgary Cumming School of Medicine
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Soheila Ajdary
Pasteur Institute of Iran
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Hamed Shafaroodi
Tehran University of Medical Sciences School of Medicine

Corresponding Author:hshafaroodi@gmail.com

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Abstract

Objectives: The objective of this study was to investigate the impact of acetylcholine signaling pathways on tumor progression, focusing on the activation of nicotinic acetylcholine receptors in breast, prostate, and lung cancer cell lines. Methods: We examined the production and release of acetylcholine in the central nervous system and its potential effects on tumors in the peripheral environment. Utilizing breast, prostate, and lung cancer cell lines, we explored the signaling pathways associated with the activation of nicotinic acetylcholine receptors. Results: Our study revealed insights into the modulation of specific tumor profiling signaling pathways through the activation of nicotinic acetylcholine receptors. We observed notable implications for patient well-being and mortality rates based on the manipulation of these pathways. Conclusion: The findings from this investigation provide valuable information on the intricate relationship between acetylcholine signaling and tumor progression. By elucidating these pathways, there is potential for targeted interventions to enhance patient outcomes and mitigate mortality rates in breast, prostate, and lung cancer cases.
03 Aug 2024Submitted to Cancer Reports
27 Aug 2024Submission Checks Completed
27 Aug 2024Assigned to Editor
27 Aug 2024Review(s) Completed, Editorial Evaluation Pending
28 Aug 2024Reviewer(s) Assigned