Abstract

Phagocytosis is an immunological characteristic that assists the host immune defense in recognizing and responding effectively to foreign pathogenic molecules and other self-antigens. Understanding the phagocytic activities against malaria infection in the context of Plasmodium falciparum infection which represents a major public health concern in many countries is crucial for developing effective interventions to prevent and control malaria, and improving the overall notion about the importance of this mechanism in the protective immune response. Previous studies have shown that various factors such as the type of phagocyte cells, plasma molecules, and the evasion of tactics by Plasmodium falciparum pathogens influence the phagocytic process. However, the mechanisms underlying phagocytic activity during Plasmodium falciparum infection are still not fully understood. This review aims to provide a comprehensive insight into the current state of knowledge on phagocytic activities in Plasmodium falciparum infection, highlighting the significant involvement of different active phagocyte cells, influences on phagocytosis, and giving perspective on the therapeutic approach and implications of this immunological activity in malaria infection clearance.