Abstract: Recent research has shown a strong link between Th17 cells and their cytokine IL-17, and various cardiovascular diseases such as myocarditis, myocardial infarction, and atherosclerosis. Moreover, Th17 cell signalling is likely to be a key factor in cardiovascular disease. Here, we summarize recent advances in the source, function, regulation, and the effects of Th17 signaling in cardiovascular disease. Research on Th17 will suggest more specific strategies to manipulate these functions. Thus, effective treatment of cardiovascular disease and future clinical treatment will be possible.