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The role of PIWI-interacting RNA in Urologic Carcinoma and its Clinical Implications
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  • Jiajia Cai,
  • Hu Fang,
  • Shirui Jiang,
  • Dongdong Lu,
  • Ghulam Murtaza,
  • Mingbang Wang,
  • Yuqing Li,
  • Da Shi,
  • Yingrui Li,
  • song wu
Jiajia Cai
Shenzhen University
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Hu Fang
Shenzhen University
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Shirui Jiang
Shenzhen University
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Dongdong Lu
Shenzhen University
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Ghulam Murtaza
Shenzhen University
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Mingbang Wang
Shenzhen University
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Yuqing Li
Shenzhen University
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Da Shi
Shenzhen University
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Yingrui Li
Shenzhen University
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song wu
Shenzhen University

Corresponding Author:wusong@szu.edu.cn

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Abstract

PIWI-interacting RNA (piRNA) is a subset of small noncoding RNA with approximately 26-30 nucleotides, and it plays a vital role in maintaining genome stability and modulating protein synthesis. Recently, emerging evidence suggested that piRNA are expressed in a tissue-specific manner across diverse human cancers, intricately modulating pivotal signaling pathways at the transcriptional or post transcriptional level. This review systematically underscores current investigations pertaining to piRNA in urologic carcinoma (UC), elucidating the proposed regulatory mechanisms encompassing N6- methyladenosine (m6A) modification and the silencing of transposable elements. Furthermore, we discussed the detection technology and the application of piRNA in the fields of clinical diagnosis.
12 Jul 2024Submitted to Cancer Reports
12 Jul 2024Submission Checks Completed
12 Jul 2024Assigned to Editor
12 Jul 2024Review(s) Completed, Editorial Evaluation Pending
25 Jul 2024Reviewer(s) Assigned