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Assessment of Optical Attenuation and Skin Thickness in Type 2 Diabetes Mellitus Patients Using Optical Coherence Tomography
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  • Minghui Chen,
  • Yue Shen,
  • Tingwei Su,
  • Yifei Zhang,
  • Weiqing Wang,
  • Chang Chen,
  • Jianguo Zhu,
  • Lin Zhou
Minghui Chen
University of Shanghai for Science and Technology School of Health Science and Engineering

Corresponding Author:cmhui.43@163.com

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Yue Shen
University of Shanghai for Science and Technology School of Health Science and Engineering
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Tingwei Su
Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital
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Yifei Zhang
Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital
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Weiqing Wang
Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital
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Chang Chen
Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital
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Jianguo Zhu
Photonic View Technology Co Ltd
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Lin Zhou
Photonic View Technology Co Ltd
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Abstract

We conducted a clinical trial with 200 type 2 diabetes patients to evaluate mμSORS for non-invasive blood glucose measurement. Using Optical Coherence Tomography, we studied skin thickness and optical attenuation in 172 diabetic and 26 healthy subjects. Results showed thicker stratum corneum and stratum spinosum in diabetics. Epidermal thickness increased with age and BMI, decreased with skin brightness, and varied minimally with gender. Optical attenuation in stratum spinosum was lower in diabetics, decreased with increasing a*, and was minimally affected by gender and BMI but increased with age in the upper dermis. These findings support mμSORS for accurate non-invasive glucose monitoring.
Submitted to Journal of Biophotonics
18 Jun 2024Submission Checks Completed
18 Jun 2024Assigned to Editor
18 Jun 2024Review(s) Completed, Editorial Evaluation Pending
17 Jul 2024Editorial Decision: Revise Major
07 Aug 20241st Revision Received
07 Aug 2024Submission Checks Completed
07 Aug 2024Assigned to Editor
07 Aug 2024Reviewer(s) Assigned
07 Aug 2024Review(s) Completed, Editorial Evaluation Pending
29 Aug 2024Editorial Decision: Accept