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The oscillatory transcranial electric stimulation and the amplitude-modulated frequency dictate the quantitative features of phosphenes
  • Che-Yi Hsu,
  • Tzu-Ling Liu,
  • Chi-Hung Juan
Che-Yi Hsu
National Central University
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Tzu-Ling Liu
National Central University
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Chi-Hung Juan
National Central University

Corresponding Author:chijuan@cc.ncu.edu.tw

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Abstract

The study explores the crucial role of current oscillation and neural alignment to amplitude-modulation frequency in phosphene induction through various forms of transcranial electric stimulation. Previous research has shown that transcranial alternating current stimulation (tACS) can modulate phosphene perception. The application of tACS introduces rhythmic electric field changes and alternating polarity, making the oscillatory mechanism behind phosphene perception still unclear. To dissociate the effects of changing electric field vs. alternating polarity, the present study employs oscillatory transcranial direct current stimulation (otDCS) to eliminate the influence of polarity switching. We administered scalp electric stimulations using tACS and otDCS in anodal or cathodal polarities over the occipital lobe. All stimulations were conducted with sinusoidal (18 Hz) or amplitude-modulated (2 Hz AM embedded in an 18 Hz carrier) waveforms at threshold or suprathreshold intensities. The results revealed no difference between stimulation polarities, suggesting the importance of current oscillation rather than polarity alteration in phosphene induction. Furthermore, amplitude-modulated stimulation consistently produced slower phosphene flash rates, unaffected by intensity, indicating the dominance of amplitude-modulation frequency in phosphene perception. Our findings suggest (1) current oscillation, rather than polarity switching, is crucial for phosphene generation; (2) amplitude-modulation frequency effects on perception threshold, response time, and perceived flash rate are robust irrespective of the oscillatory stimulation protocols; (3) amplitude-modulation information is encoded in phosphene perception generation independently of the carrier frequency. This study provides direct evidence of the link between phosphene occurrence and oscillatory current activity, underscoring the robustness and independence of amplitude-modulation coding in visual perception.
Submitted to European Journal of Neuroscience
16 Jun 2024Review(s) Completed, Editorial Evaluation Pending
17 Jun 2024Editorial Decision: Revise Major
22 Sep 20241st Revision Received
24 Sep 2024Submission Checks Completed
24 Sep 2024Assigned to Editor
24 Sep 2024Review(s) Completed, Editorial Evaluation Pending
24 Sep 2024Reviewer(s) Assigned
09 Nov 2024Editorial Decision: Revise Major
27 Nov 20242nd Revision Received
30 Nov 2024Assigned to Editor
30 Nov 2024Submission Checks Completed
30 Nov 2024Review(s) Completed, Editorial Evaluation Pending
30 Nov 2024Reviewer(s) Assigned
12 Dec 2024Editorial Decision: Accept