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Effects of Photobiomodulation Application on Glutathione-Related Antioxidant Defense System in Rabbit Eye Tissues
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  • Mehmet Ozcan,
  • Ayse Burus,
  • Etkin Boynuyogun,
  • Mert Calis,
  • Figen Ozgur,
  • Yasemin Aksoy
Mehmet Ozcan
Zonguldak Bulent Ecevit Universitesi Tip Fakultesi

Corresponding Author:biochemistmozcan@gmail.com

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Ayse Burus
Hacettepe Universitesi Tip Fakultesi
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Etkin Boynuyogun
Hacettepe Universitesi Tip Fakultesi
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Mert Calis
Hacettepe Universitesi Tip Fakultesi
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Figen Ozgur
Hacettepe Universitesi Tip Fakultesi
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Yasemin Aksoy
Hacettepe Universitesi Tip Fakultesi
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Abstract

Photobiomodulation (PBM) has emerged as a potentially effective therapeutic approach to modulate cellular functions. This study aimed to examine the impact of PBM on reactive oxygen species (ROS) and lipid peroxidation, and glutathione-related antioxidant defense systems in rabbit eye tissues. A polychromatic light source with an intensity of 2.6 J/cm 2/min was used for PBM treatment in New Zealand White rabbits for 12 minutes. The PBM group (n=8) received treatments every two days for a total of twelve sessions, while the control group (n=8) did not undergo any PBM light exposure during the same period. The application of PBM significantly elevated ROS-mediated glutathione levels, along with increased activities of glutathione peroxidase and reductase, particularly in corneal tissue ( p ≤ 0.05). In conclusion, these findings could enhance understanding of PBM’s therapeutic potential for eye health and lead to new strategies for preventing or treating ocular diseases caused by oxidative stress.
13 Jun 2024Submitted to Journal of Biophotonics
14 Jun 2024Submission Checks Completed
14 Jun 2024Assigned to Editor
14 Jun 2024Review(s) Completed, Editorial Evaluation Pending
14 Jun 2024Reviewer(s) Assigned
11 Jul 2024Editorial Decision: Revise Major
05 Aug 20241st Revision Received
06 Aug 2024Submission Checks Completed
06 Aug 2024Assigned to Editor
06 Aug 2024Reviewer(s) Assigned
06 Aug 2024Review(s) Completed, Editorial Evaluation Pending
13 Aug 2024Editorial Decision: Accept