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Non-invasive Capillary Mapping in Skin Tumors Located in Arbitrary Areas of Human Body
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  • Anastasia Guryleva,
  • Alexander Machikhin,
  • Ekaterina Orlova,
  • Evgeniya Kulikova,
  • Mikhail Volkov,
  • Gayane Gabrielian,
  • Ludmila Smirnova,
  • Mariya Sekacheva,
  • Olga Olisova,
  • Ekaterina Rudenko,
  • Olga Lobanova,
  • Tatiana Demura
Anastasia Guryleva
FGBUN Naucno-tehnologiceskij centr unikal'nogo priborostroenia Rossijskoj akademii nauk

Corresponding Author:guryleva.av@ntcup.ru

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Alexander Machikhin
FGBUN Naucno-tehnologiceskij centr unikal'nogo priborostroenia Rossijskoj akademii nauk
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Ekaterina Orlova
Pervyj Moskovskij gosudarstvennyj medicinskij universitet imeni I M Secenova
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Evgeniya Kulikova
FGBUN Naucno-tehnologiceskij centr unikal'nogo priborostroenia Rossijskoj akademii nauk
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Mikhail Volkov
FGBUN Naucno-tehnologiceskij centr unikal'nogo priborostroenia Rossijskoj akademii nauk
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Gayane Gabrielian
Pervyj Moskovskij gosudarstvennyj medicinskij universitet imeni I M Secenova
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Ludmila Smirnova
Pervyj Moskovskij gosudarstvennyj medicinskij universitet imeni I M Secenova
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Mariya Sekacheva
Pervyj Moskovskij gosudarstvennyj medicinskij universitet imeni I M Secenova
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Olga Olisova
Pervyj Moskovskij gosudarstvennyj medicinskij universitet imeni I M Secenova
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Ekaterina Rudenko
Pervyj Moskovskij gosudarstvennyj medicinskij universitet imeni I M Secenova
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Olga Lobanova
Pervyj Moskovskij gosudarstvennyj medicinskij universitet imeni I M Secenova
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Tatiana Demura
Pervyj Moskovskij gosudarstvennyj medicinskij universitet imeni I M Secenova
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Abstract

Non-invasive, rapid and robust diagnostic techniques for clinical screening of tumors located in arbitrary areas of the human body are in demand. To address this challenge, we analyzed the feasibility of vessel mapping by means of time-lapse digital microscopy for assessing vascular patterns within malignant and benign tumors. The proposed hardware and software were approved in a clinical study involving 30 patients with tumors located in legs, torso, arms, and head. High-contrast and detailed vessel maps within both benign and malignant tumors were obtained. We demonstrated that capillary maps are consistent and can be interpreted using well-established dermoscopic criteria for the vascular morphology. Vessel mapping provides valuable details, which may not be available in dermoscopic images and can aid in determining whether a tumor is benign or malignant. We believe that the proposed approach may become a valuable tool in the preliminary cancer diagnosis and is suitable for large-scale screening.
Submitted to Journal of Biophotonics
06 Jun 2024Assigned to Editor
06 Jun 2024Submission Checks Completed
06 Jun 2024Review(s) Completed, Editorial Evaluation Pending
04 Jul 2024Editorial Decision: Revise Major
01 Aug 20241st Revision Received
01 Aug 2024Submission Checks Completed
01 Aug 2024Assigned to Editor
01 Aug 2024Reviewer(s) Assigned
01 Aug 2024Review(s) Completed, Editorial Evaluation Pending
25 Aug 2024Editorial Decision: Revise Minor
05 Sep 20242nd Revision Received
06 Sep 2024Submission Checks Completed
06 Sep 2024Assigned to Editor
06 Sep 2024Review(s) Completed, Editorial Evaluation Pending
06 Sep 2024Editorial Decision: Accept