loading page

Oligonucleotide-Based Modulation of Macrophage Polarization: Emerging Strategies in Immunotherapy
  • Hanfu Zhang,
  • Cheng Qian
Hanfu Zhang
The University of Western Australia
Author Profile
Cheng Qian
Naval Medical University

Corresponding Author:crystalqiancheng@163.com

Author Profile

Abstract

Recent advancements in immunotherapy spotlight the pivotal role of macrophages in disease treatment. The polarization of macrophages, wherein these immune cells differentiate into either pro-inflammatory (M1) or anti-inflammatory (M2) states, plays a vital role in the therapeutic modulation of a spectrum of diseases. Oligonucleotides have emerged as potent tools for modulating macrophage polarization with high specificity and potential cost-effectiveness compared to traditional therapies. In this review, we delve into the application of oligonucleotides for steering macrophage polarization, introducing how macrophage is polarized and how 4 different kinds of oligonucleotide (ASO, siRNA, agomir/antagomir and aptamer) works, discusses their therapeutic potentials and challenges associated with these strategies, emphasizing the importance of precise, disease-specific interventions by presenting actual examples. While the application of oligonucleotides in clinical faces challenges, we also highlights some recent, significant advances in current trials and the future potential in stimulating macrophages for therapeutic advantages in immunotherapy, signaling a frontier in disease treatment and management.
Submitted to Immunity, Inflammation and Disease
Submission Checks Completed
Assigned to Editor
Reviewer(s) Assigned
26 Jul 2024Reviewer(s) Assigned