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Role of Wnt5a in inflammatory diseases
  • +3
  • Kui Li,
  • Xin-ning Guo,
  • Jia-wei Li,
  • Kaijin Wang,
  • Xin-hua Yu,
  • Bi-cui Liu
Kui Li
Bishan Hospital of Chongqing Medical University
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Xin-ning Guo
Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital
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Jia-wei Li
Bishan Hospital of Chongqing Medical University
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Kaijin Wang
Bishan Hospital of Chongqing Medical University
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Xin-hua Yu
Bishan Hospital of Chongqing Medical University
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Bi-cui Liu
Bishan Hospital of Chongqing Medical University

Corresponding Author:liuyuan2469@163.com

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Abstract

Wnt5a plays an important role in the process of cell development and maturation and is closely related to various diseases, such as malignant tumors, metabolic disorders, fibrosis, growth and development. Recent studies have shown that Wnt5a expression regulation and signal transduction are closely related to inflammatory response. This paper comprehensively reviews the latest research progress on the relationship between Wnt5a and various inflammatory diseases, such as sepsis, asthma, chronic obstructive pulmonary disease, tuberculosis, rheumatoid arthritis, atherosclerosis, psoriasis vulgare, etc. The mechanism of Wnt5a protein in the pathogenesis of these diseases was elucidated, which provided a basis for the prevention and treatment of inflammatory diseases with Wnt5a as a possible target in the future.
Submitted to Immunology
Submission Checks Completed
Assigned to Editor
Reviewer(s) Assigned
22 Jun 2024Review(s) Completed, Editorial Evaluation Pending
14 Jul 2024Reviewer(s) Assigned
23 Aug 2024Editorial Decision: Revise Minor
02 Oct 20241st Revision Received
08 Oct 2024Submission Checks Completed
08 Oct 2024Assigned to Editor
08 Oct 2024Review(s) Completed, Editorial Evaluation Pending
08 Oct 2024Reviewer(s) Assigned
22 Nov 2024Editorial Decision: Accept