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Self-Activated Multifunctional PHC Bandage for Accelerated Wound Healing in Movable Parts
  • +11
  • liqi Wei,
  • Xin Liu,
  • Yuanqiang Li,
  • Yu Han,
  • Yiping Ren,
  • Tianshu Zou,
  • Pengcheng Yu,
  • Yining Chen,
  • Biao Zhang,
  • Zixuan Wang,
  • Jingyi Jiang,
  • Rui Chen,
  • Yan Cheng,
  • Hongxia Ma
Xin Liu
Jilin Agricultural University
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Yuanqiang Li
Jilin Agricultural University
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Yu Han
Jilin Agricultural University
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Yiping Ren
Jilin Agricultural University
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Tianshu Zou
Jilin Agricultural University
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Pengcheng Yu
Chang Chun University
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Yining Chen
Jilin Agricultural University
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Biao Zhang
Jilin Agricultural University
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Zixuan Wang
Jilin Agricultural University
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Jingyi Jiang
Jilin Agricultural University
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Rui Chen
Chang Chun University
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Yan Cheng
Jilin Agricultural University

Corresponding Author:ycheng@jlau.edu.cn

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Hongxia Ma
Jilin Agricultural University
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Abstract

Wound healing in movable parts poses challenges due to frequent activities, leading to delayed recovery and heightened susceptibility to bacterial infections and inflammation. Although hydrogel-based dressings have been explored, their therapeutic effectiveness is limited by their poor resistance to stimuli and low mechanical strength. Here, to address this issue, we present a novel self-activated multifunctional PHC bandage that not only prevents bacterial infection but also capitalizes on the inherent mobility of the affected area to expedite the wound healing process. The PHC bandage was fabricated by incorporating photothermal copper bismuth sulfide (Cu3BiS3) nanoparticles (NPs) into piezoelectric and pyroelectric polyvinylidene fluoride (PVDF). Upon exposure to near-infrared light, the embedded Cu3BiS3 nanoparticles generate localized heat, activating the PVDF and inducing the production of abundant reactive oxygen species for bacterial inactivation. Furthermore, the continuous movement of the wounded area triggers the PVDF to generate a sustained electrical field, promoting cell migration and proliferation to facilitate wound healing. Importantly, the robust encapsulation of PVDF ensures secure containment of the loaded Cu3BiS3 nanoparticles, improving the biocompatibility and sustainable utilization of this innovative wound dressing. This innovative design offers a promising and effective solution to improve wound healing in movable parts, potentially revolutionizing wound care technology.
Submitted to Exploration
08 Feb 20241st Revision Received
20 Feb 2024Reviewer(s) Assigned
23 Feb 2024Review(s) Completed, Editorial Evaluation Pending
26 Apr 20242nd Revision Received
08 May 2024Editorial Decision: Revise Major
18 May 20243rd Revision Received
19 May 2024Submission Checks Completed
19 May 2024Assigned to Editor
19 May 2024Review(s) Completed, Editorial Evaluation Pending
24 Jun 2024Editorial Decision: Accept