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University Teaching of Mass Spectrometry as a Key Practical Technique within the Context of a Fully-Integrated, Spiral Curriculum.
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  • Andrew F. Worrall,
  • Craig D. Campbell,
  • Megan O. Midson,
  • Malcolm I. Stewart
Andrew F. Worrall
University of Oxford Department of Chemistry

Corresponding Author:andrew.worrall@chem.ox.ac.uk

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Craig D. Campbell
University of Oxford Department of Chemistry
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Megan O. Midson
University of Oxford Department of Chemistry
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Malcolm I. Stewart
University of Oxford Department of Chemistry
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Abstract

Rationale: Mass spectrometry (MS) is introduced to high school students in the UK in many pre-university course syllabi. As such, we have identified the use of MS as a key technique that should be taught practically to undergraduates from the outset of their studies. This mini‑review describes how we introduce and develop students’ use of MS throughout our three‑year undergraduate spiral curriculum practical program, using atmospheric pressure chemical ionisation MS (APCI/MS). Methods: We have used an Advion Expression L spectrometer, fitted with an atmospheric solids analysis probe or a Plate Express TLC sampler for sample introduction. Results: We have successfully demonstrated the use of APCI-MS in a range of practicals and experiments covering organic and organometallic chemistries, with large cohorts of students gaining hands‑on instrumental experience in authentic research settings. Conclusions: APCI-MS has proven to be an easy-to-use and valuable addition to our undergraduate practical course. The robustness of the spectrometer enables routine use by large cohorts of students with minimal supervision, and routine maintenance can be carried out by non-specialist technicians. Students can readily process and interpret results for a series of routine analyses, as well as demonstrate uses in problem-solving exercises.
Submitted to Rapid Communications in Mass Spectrometry
25 Apr 2024Submission Checks Completed
25 Apr 2024Assigned to Editor
25 Apr 2024Review(s) Completed, Editorial Evaluation Pending
25 Apr 2024Reviewer(s) Assigned
26 May 2024Editorial Decision: Revise Minor
28 May 2024Review(s) Completed, Editorial Evaluation Pending