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Can transcutaneous auricular vagus nerve stimulation mitigate vigilance loss? Examining the effects of stimulation at individualized vs. constant current intensity
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  • Fernando Luna,
  • Juan Lupianez,
  • Stefanie König,
  • Ulrike Garscha,
  • rico fischer
Fernando Luna
University of Greifswald

Corresponding Author:fluna@unc.edu.ar

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Juan Lupianez
University of Granada
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Stefanie König
University of Greifswald Institute of Pharmacy
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Ulrike Garscha
University of Greifswald Institute of Pharmacy
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rico fischer
University of Greifswald
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Abstract

According to the arousal model of vigilance, the locus coeruleus-norepinephrine (LC-NE) system modulates sustained attention over long periods by regulating physiological arousal. Recent research has proposed that transcutaneous auricular vagus nerve stimulation (taVNS) modulates indirect physiological markers of LC-NE activity, although its effects on vigilance have not yet been examined. Aiming to develop a safe and non-invasive procedure to prevent vigilance failures in prolonged tasks, the present study examined the possibility to mitigate vigilance loss by stimulating the LC-NE system via taVNS. Following a pre-registered protocol (https://osf.io/tu2xy/), 50 participants completed three repeated-sessions in a randomized order in which either active taVNS at individualized intensity set by participant, active taVNS set at 0.5 mA for all participants, or sham taVNS, was delivered while performing an attentional and vigilance task (i.e., ANTI-Vea). Changes in salivary alpha-amylase and cortisol concentrations were measured as markers of LC-NE activity. Self-reports of feelings associated with stimulation and guessing rate of active/sham conditions supported the efficacy of the single-blind procedure. Contrary to our predictions, the observed vigilance decrement was not modulated by active taVNS. Pairwise comparisons showed a mitigation by active taVNS on cortisol reduction across time. Interestingly, Spearman’s correlational analyses showed some inter-individual effects of taVNS on indirect markers of LC-NE, evidenced by positive associations between changes in salivary alpha-amylase and cortisol in active but not sham taVNS. We highlight the relevance of replicating and extending the present outcomes, investigating further parameters of stimulation and its effects on other indirect markers of LC-NE activity.
11 Apr 2024Submitted to Psychophysiology
12 Apr 2024Submission Checks Completed
12 Apr 2024Assigned to Editor
12 Apr 2024Review(s) Completed, Editorial Evaluation Pending
20 Apr 2024Reviewer(s) Assigned
05 Aug 20241st Revision Received
06 Aug 2024Submission Checks Completed
06 Aug 2024Assigned to Editor
06 Aug 2024Review(s) Completed, Editorial Evaluation Pending
07 Aug 2024Editorial Decision: Accept