Homoploid hybrid speciation is challenging to document because hybridization can lead to outcomes other than speciation. Thus, some authors have argued that establishment of homoploid hybrid speciation should include evidence that reproductive barriers isolating the hybrid neo-species from its parental species were derived from hybridization. While this criterion is difficult to satisfy, several recent papers have successfully employed a common pipeline to identify candidate genes underlying such barriers and (in one case) to validate their function. We describe this pipeline, its application to several plant and animal species, and what we have learned about homoploid hybrid speciation as a consequence. We argue that—-given the ubiquity of admixture and the polygenic basis of reproductive isolation—-homoploid hybrid speciation could be much more common and more protracted than suggested by earlier conceptual arguments and theoretical studies.