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Clinical and Etiological Characteristics of Severe Hemorrhagic Fever Caused by Coinfection of Thrombocytopenia Syndrome Bunyavirus and Hemorrhagic Fever Virus
  • +8
  • Feng Jiang,
  • Xiaohu Han,
  • Yongxiang Zhao,
  • Ruihao Peng,
  • Qijun Chen,
  • Ya Wen,
  • Yudan Bi,
  • Yichen Zhou,
  • Yao Chen,
  • Hua Deng,
  • Zeliang Chen
Feng Jiang
Shenyang Agricultural University

Corresponding Author:jf8849@syau.edu.cn

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Xiaohu Han
Shenyang Agricultural University
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Yongxiang Zhao
3The Sixth People's Hospital of Dandong City
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Ruihao Peng
Sun Yat-Sen University School of Public Health
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Qijun Chen
Shenyang Agricultural University
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Ya Wen
3The Sixth People's Hospital of Dandong City
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Yudan Bi
Shenyang Agricultural University
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Yichen Zhou
Shenyang Agricultural University
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Yao Chen
5Liaoning center for Agricultural Development Service
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Hua Deng
6Manzhouli international travel health care center
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Zeliang Chen
Shenyang Agricultural University
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Abstract

Objective: Severe fever with thrombocytopenia syndrome (SFTS) and hemorrhagic fever with renal syndrome (HFRS) usually have different infection routes, and coinfection is relatively rare. The clinical and etiological characteristics of coinfection by the two pathogens will provide important references for clinical diagnosis and treatment. Methods: Blood samples and epidemiological data on HFRS patients were collected and classified into severe and non-severe groups according to clinical severity. The differences in clinical characteristics and levels of pathogens were evaluated and compared. Results: A total of 22 HFRS patient cases were collected from December 2021 to October 2022. Of these patients, 16 were non-severe and 6 severe. Patients with rodent exposure history, muscle and joint pain, weight loss, pharyngeal and conjunctival hyperemia, and positive urine protein and antibody IGM had a high severe rate (P< 0.05). Molecular tests on blood samples showed that 3 of the 6 severe patients were positive for hantavirus, 2 of the 3 hantavirus positives were positive for bunyavirus. Conclusion: Severe HFRS patients have different epidemiological, clinical, and laboratory characteristics. The coinfection of hantavirus and bunyavirus leads to severe HFRS. These findings have implications and references for diagnosis and treatment of coinfected severe cases.
Submitted to Journal of Medical Virology
10 Mar 2024Review(s) Completed, Editorial Evaluation Pending
10 Mar 2024Editorial Decision: Revise Major
09 Jul 20241st Revision Received
10 Jul 2024Submission Checks Completed
10 Jul 2024Assigned to Editor
10 Jul 2024Review(s) Completed, Editorial Evaluation Pending
10 Jul 2024Reviewer(s) Assigned
01 Aug 2024Editorial Decision: Revise Minor
03 Aug 20242nd Revision Received
23 Aug 2024Submission Checks Completed
23 Aug 2024Assigned to Editor
23 Aug 2024Review(s) Completed, Editorial Evaluation Pending
23 Aug 2024Reviewer(s) Assigned
11 Sep 2024Editorial Decision: Accept