loading page

Juvenile xanthogranuloma manifesting with LCH-associated neurodegenerative disease-like radiological findings
  • +7
  • Katsutsugu Umeda,
  • Tomoo Daifu,
  • Atsushi Yokoyama,
  • Takeshi Yoshida,
  • Satoshi Saida,
  • Itaru Kato,
  • Hidefumi Hiramatsu,
  • Ko Kudo,
  • Yoshihisa Higuchi,
  • Junko Takita
Katsutsugu Umeda
Kyoto Daigaku Daigakuin Igaku Kenkyuka Igakubu Hattatsu Shoni Kagaku

Corresponding Author:umeume@kuhp.kyoto-u.ac.jp

Author Profile
Tomoo Daifu
Otsu Sekijuji Byoin
Author Profile
Atsushi Yokoyama
Kyoto Daigaku Daigakuin Igaku Kenkyuka Igakubu Hattatsu Shoni Kagaku
Author Profile
Takeshi Yoshida
Kyoto Daigaku Daigakuin Igaku Kenkyuka Igakubu Hattatsu Shoni Kagaku
Author Profile
Satoshi Saida
Kyoto Daigaku Daigakuin Igaku Kenkyuka Igakubu Hattatsu Shoni Kagaku
Author Profile
Itaru Kato
Kyoto Daigaku Daigakuin Igaku Kenkyuka Igakubu Hattatsu Shoni Kagaku
Author Profile
Hidefumi Hiramatsu
Kyoto Daigaku Daigakuin Igaku Kenkyuka Igakubu Hattatsu Shoni Kagaku
Author Profile
Ko Kudo
Hirosaki Daigaku Igakubu Daigakuin Igaku Kenkyuka
Author Profile
Yoshihisa Higuchi
Otsu Sekijuji Byoin
Author Profile
Junko Takita
Kyoto Daigaku Daigakuin Igaku Kenkyuka Igakubu Hattatsu Shoni Kagaku
Author Profile

Abstract

Here, we describe two patients with juvenile xanthogranuloma (JXG) manifesting with Langerhans cell histiocytosis-associated neurodegenerative disease (ND)-like radiological findings. One patient showed typical radiological abnormalities at onset, which worsened with progressing central nervous system symptoms 7 years after LCH-oriented chemotherapy. Another showed spontaneous regression of clinical symptoms, with a transient radiological change 1 year after salvage chemotherapy for recurrence of JXG. These data regarding JXG-associated ND will facilitate future investigation of the disease, as well as development of therapeutic interventions.
21 Feb 2024Submission Checks Completed
21 Feb 2024Assigned to Editor
21 Feb 2024Submitted to Pediatric Blood & Cancer
22 Feb 2024Reviewer(s) Assigned
06 Mar 2024Review(s) Completed, Editorial Evaluation Pending
08 Mar 2024Editorial Decision: Revise Minor
27 Mar 2024Reviewer(s) Assigned
28 Mar 2024Review(s) Completed, Editorial Evaluation Pending
08 Apr 20242nd Revision Received
08 Apr 2024Review(s) Completed, Editorial Evaluation Pending
10 Apr 2024Reviewer(s) Assigned
12 Apr 2024Editorial Decision: Accept