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Primary Thymic Germinoma in an 11-year-old boy with Lowe Syndrome
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  • Toshiko Takezoe,
  • Toshihiko Watanabe,
  • Katsuhiro Ogawa,
  • Kotaro Tomonaga,
  • Mioko Nomura,
  • Michinobu Ohno,
  • Kazunori Tahara,
  • Tomoro Hishiki,
  • Akihiro Fujino,
  • Tetsuya Ishimaru,
  • Yutaka Kanamori
Toshiko Takezoe
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Seiiku Iden Kenkyubu
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Toshihiko Watanabe
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Seiiku Iden Kenkyubu
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Katsuhiro Ogawa
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Seiiku Iden Kenkyubu
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Kotaro Tomonaga
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Seiiku Iden Kenkyubu
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Mioko Nomura
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Seiiku Iden Kenkyubu
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Michinobu Ohno
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Seiiku Iden Kenkyubu
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Kazunori Tahara
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Seiiku Iden Kenkyubu
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Tomoro Hishiki
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Seiiku Iden Kenkyubu
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Akihiro Fujino
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Seiiku Iden Kenkyubu
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Tetsuya Ishimaru
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Seiiku Iden Kenkyubu
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Yutaka Kanamori
Kokuritsu Kenkyu Kaihatsu Hojin Kokuritsu Seiiku Iryo Kenkyu Center Seiiku Iden Kenkyubu

Corresponding Author:kanamori-y@ncchd.go.jp

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Abstract

An 11-year-old boy with Lowe syndrome developed secondary sexual characteristics within a few weeks, suggestive of precocious puberty. His blood tests were positive for serum-human chorionic gonadotropin, and imaging revealed a right thymic lobe mass containing small cystic lesions. A germ cell tumor with malignant potential was suspected. Thus, we performed an extended thymectomy with mediastinal lymph node dissection and confirmed germinoma of the right thymic lobe without lymph node metastasis; the patient underwent four courses of chemotherapy. Follow-up evaluations indicated no recurrence. Thus, we present a highly rare case report of thymic germinoma complicated by Lowe syndrome.
08 Feb 2024Submission Checks Completed
08 Feb 2024Assigned to Editor
15 Feb 2024Submitted to Pediatric Blood & Cancer
16 Feb 2024Review(s) Completed, Editorial Evaluation Pending
16 Feb 2024Editorial Decision: Revise Minor
29 Feb 20241st Revision Received
01 Mar 2024Submission Checks Completed
01 Mar 2024Assigned to Editor
05 Mar 2024Editorial Decision: Accept