loading page

THE VALUE OF URINE ANALYSIS PREDICTING ACUTE KIDNEY INJURY AND MORTALITY IN COVID-19 PATIENTS
  • Meric Oruc,
  • AYŞE BATIREL,
  • Sinan Trabulus
Meric Oruc

Corresponding Author:mericozd@yahoo.com

Author Profile
AYŞE BATIREL
Kartal Dr.Lutfi Kirdar City Hospital,
Author Profile
Sinan Trabulus
Istanbul University-Cerrahpasa Cerrahpasa Faculty of Medicine
Author Profile

Abstract

ABSTRACT Purpose Kidney involvement is frequent among patients with coronavirus disease 2019 (Covid-19). However, kidney involvement is varied and mild kidney injury can easily go unnoticed. We aimed to investigate the urinalysis data of Covid-19 patients on admission and to explore the value of urinalysis in the prediction of AKI and in-hospital mortality in patients with Covid-19. Methods The demographic, clinical and laboratory data of patients with confirmed Covid-19 were collected from the electronic health records of the hospital. The outcomes were development of AKI and in-hospital mortality. Results 244 patients were included in the analysis. Mean age was 59.6 ± 13.7 and 65.2% of patients were male. Median SCr on admission was 0.86 (0.72-1.05) mg/dL. Glucosuria, proteinuria and hematuria were found in 36.1%, 22.9% and 22.1% of patients, respectively. AKI was detected in 63 patients (25.8%) on any time of hospitalization. According to multivariate binary logistic regression analayses; AKI development was associated with higher WBC and decreased eGFR as well as with proteinuria on admission. During median 8 (IQR, 5-12) days of follow-up, 33 patients (13.5%) died. Older age, higher CRP levels and proteinuria on admission were also independent predictors of in-hospital mortaliy. Conclusion Proteinuria on admission is associated with development of AKI and in-hospital mortality in patients with Covid-19. Urinalysis can be useful for the evaluation of COVID-19 progression and early diagnosis of kidney damage before SCr rise.