loading page

Efficacy of Dupilumab plus topical corticosteroids in children with atopic dermatitis: a meta-analysis of randomized controlled trials
  • Li Wang,
  • Si-Ning Wang,
  • Zhang Ruili
Li Wang
The Second Affiliated Hospital of Nanjing Medical University
Author Profile
Si-Ning Wang
The Second Affiliated Hospital of Nanjing Medical University
Author Profile
Zhang Ruili
The Second Affiliated Hospital of Nanjing Medical University

Corresponding Author:rellyzhang@njmu.edu.cn

Author Profile

Abstract

Introduction: Children with atopic dermatitis(AD) suffer from a high illness burden that has a detrimental influence on their quality of life . Objective: To determine whether topical corticosteroids and dupilumab are effective for treating atopic dermatitis in children. Methods: Web of Science, PubMed, and Embase, three well-known databases, were used to conduct a thorough literature search. Using a fixed-effects or random-effects model, the standard mean difference (SMD) or risk ratios (RR) with 95% confidence interval (CI) were calculated.PROSPERO lists the trial protocol as CRD42023408546. Results: There were 3 investigations in total, and 896 people met the requirements for inclusion.The combined estimate showed that dupilumab plus topical corticosteroids had numerically greater efficacy in terms of EASI-50, EASI-75, EASI-90, and Investigator Global Assessment (IGA) score of 0 or 1.When compared to placebo, children who got topical corticosteroids and dupilumab scored considerably higher on the dermatological life quality index (CDLQI). The number of individuals who achieved IGA0/1 rose with the use of dupilumab and topical corticosteroids. Conclusions:In children with AD, dipilumab and topical corticosteroids may be used to treat the symptoms. Given the substantial variation between the research, the findings should, however, be regarded with caution.
12 Sep 2023Submitted to Immunity, Inflammation and Disease
12 Sep 2023Submission Checks Completed
12 Sep 2023Assigned to Editor
12 Sep 2023Review(s) Completed, Editorial Evaluation Pending
16 Sep 2023Reviewer(s) Assigned
31 Oct 2023Editorial Decision: Revise Minor
17 Nov 20231st Revision Received
19 Nov 2023Submission Checks Completed
19 Nov 2023Assigned to Editor
19 Nov 2023Review(s) Completed, Editorial Evaluation Pending
19 Nov 2023Reviewer(s) Assigned