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Vogt–Koyanagi–Harada Disease after SARS-CoV-2 Infection: Case Report
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  • Hui Zou,
  • Ke Zhang,
  • Xuan Chen,
  • Sha Sha
Hui Zou
Hunan Provincial People’s Hospital (The First Hospital of Hunan Normal University)
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Ke Zhang
Hunan Provincial People’s Hospital (The First Hospital of Hunan Normal University)
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Xuan Chen
Hunan Provincial People’s Hospital (The First Hospital of Hunan Normal University)
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Sha Sha
Hunan Provincial People’s Hospital (The First Hospital of Hunan Normal University)

Corresponding Author:shasha7892@163.com

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Abstract

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19), a multifaceted condition. The COVID-19 is associated with various ocular manifestations including conjunctivitis, retinal vein occlusion and optic neuritis. The case of VKH disease associated with SARS-CoV-2 was rare and the specific association is still unclear. Case Presentation In the present study, a 35-year-old female patient with no significant medical history presented with one week of bilateral blurred vision 2 weeks after a clinical course of COVID-19. Both eyes presented with bullous serous retinal detachments. She was diagnosed with incomplete Vogt–Koyanagi–Harada (VKH) disease. Early diagnosis and treatment of VKH disease are essential for the visual prognosis of this aggressive disease. Ocular inflammatory signs and visual acuity improved via corticosteroid therapy in this patient. The case of VKH disease associated with SARS-CoV-2 was rare and the specific association is still unclear. By reviewing similar studies previously reported, we discuss and summarize the potential mechanisms explaining the association between VKH disease and SARS-CoV-2. Conclusion Although the causality remains unclear, ophthalmologists and physicians should be aware of this possible association between VKH disease and COVID-19. SARS-CoV-2 may play a potential immunological triggering role in VKH disease. However, further in-depth researches are necessary to investigate the clinical and epidemiological features, as well as the underlying mechanisms of it. Keywords: Vogt–Koyanagi–Harada disease; SARS-CoV-2; COVID-19; case report
16 Jul 2023Submitted to Immunity, Inflammation and Disease
26 Jul 2023Submission Checks Completed
26 Jul 2023Assigned to Editor
26 Jul 2023Review(s) Completed, Editorial Evaluation Pending
10 Aug 2023Reviewer(s) Assigned
14 Sep 2023Editorial Decision: Revise Major
03 Oct 20231st Revision Received
09 Oct 2023Submission Checks Completed
09 Oct 2023Assigned to Editor
09 Oct 2023Review(s) Completed, Editorial Evaluation Pending
02 Mar 2024Editorial Decision: Revise Major
20 Mar 20242nd Revision Received
21 Mar 2024Assigned to Editor
21 Mar 2024Submission Checks Completed
21 Mar 2024Review(s) Completed, Editorial Evaluation Pending
31 Mar 2024Editorial Decision: Accept