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Interaction between long non-coding RNA and microRNA in lung diseases
  • +4
  • Jiaqi Li,
  • Xiaoxiao Liu,
  • Liangliang Shi,
  • Guochang Chen,
  • Shengyu Huang,
  • Mingzhuo Liu,
  • Guanghua Guo
Jiaqi Li
First Affiliated Hospital of Nanchang University
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Xiaoxiao Liu
First Affiliated Hospital of Nanchang University
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Liangliang Shi
First Affiliated Hospital of Nanchang University
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Guochang Chen
First Affiliated Hospital of Nanchang University
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Shengyu Huang
First Affiliated Hospital of Nanchang University
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Mingzhuo Liu
First Affiliated Hospital of Nanchang University
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Guanghua Guo
First Affiliated Hospital of Nanchang University

Corresponding Author:ndyfy00655@ncu.edu.cn

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Abstract

Non-coding RNAs are a group of RNAs that cannot synthesize proteins, but are critical in the regulation of gene expression. A growing number of studies discovered that miRNAs and lncRNAs, as the two major members of the ncRNA family, play vital roles in regulating the physiological and pathological processes of lung diseases, such as pneumonia, COPD (chronic obstructive pulmonary disease), lung cancer, and asthma. These interactions are intricately linked to the the regulation of immune response, cell proliferation and apoptosis, cell differentiation and polarization, cytokine secretion, or acts as tumor suppressors or promoters. Understanding the role of ncRNAs in lung diseases might provide novel insights into disease mechanisms and potential therapeutic targets. In this review, we will go over the fundamental characteristics and functions of miRNAs and lncRNAs, their potential interaction mechanisms, then summarize the newly explorations on the role of these interactions between lncRNAs and miRNAs in various lung diseases.
28 May 2023Submitted to Immunity, Inflammation and Disease
29 May 2023Submission Checks Completed
29 May 2023Assigned to Editor
29 May 2023Review(s) Completed, Editorial Evaluation Pending
05 Jun 2023Reviewer(s) Assigned
29 Aug 2023Editorial Decision: Revise Major
06 Nov 20231st Revision Received
09 Nov 2023Submission Checks Completed
09 Nov 2023Assigned to Editor
09 Nov 2023Review(s) Completed, Editorial Evaluation Pending
09 Nov 2023Reviewer(s) Assigned
22 Nov 2023Editorial Decision: Revise Major