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Predictive value of haematological indices on incidence and severity of pulmonary embolism in COVID-19 patients
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  • Hanieh Radkhah,
  • Ensieh Sadat Mansouri,
  • Shiva Rahimipour Anaraki,
  • Milad Gholizadeh,
  • Ali Sheikhy,
  • Mohamad Mehdi Khadembashiri,
  • Mohamad Amin Khadembashiri,
  • Mohamad Eslami,
  • Tara Mahmoodi,
  • Behnaz Inanloo
Hanieh Radkhah
Tehran University of Medical Sciences
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Ensieh Sadat Mansouri
Tehran University of Medical Sciences
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Shiva Rahimipour Anaraki
Iran University of Medical Sciences
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Milad Gholizadeh
Iran University of Medical Sciences

Corresponding Author:drmiladgholizadeh@gmail.com

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Ali Sheikhy
Tehran University of Medical Sciences
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Mohamad Mehdi Khadembashiri
Tehran University of Medical Sciences
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Mohamad Amin Khadembashiri
Tehran University of Medical Sciences
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Mohamad Eslami
Tehran University of Medical Sciences
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Tara Mahmoodi
Tehran University of Medical Sciences
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Behnaz Inanloo
Tehran University of Medical Sciences
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Abstract

Background: Pulmonary thromboembolism (PTE) is a common complication of SARS-CoV-2, which raises the COVID-19 disease’s fatality rate from 3% to 45%. Nevertheless, due to fairly indistinguishable clinical symptoms and a lack of validated clinical prediction models, PTE diagnosis in COVID-19 patients is challenging. This study aims to investigate the applicability of hematological indices to predict PTE incidence and its severity in SARS-CoV-2 patients. Methods: A retrospective cohort study was conducted on hospitalized patients with a confirmed diagnosis of SARS-CoV-2 infection who underwent CT angiography to assess probable PTE in them. The correlation between CBC parameters one day prior to CT angiography and CT angiography outcomes, and simplified Pulmonary Embolism Severity Index (s-PESI) was investigated. Results: We discovered that among individuals with a probable PTE, males and those with higher platelet-to-lymphocyte (PLR) and neutrophil-to-lymphocyte (NLR) ratios had a greater likelihood of PTE incidence. PLR was a significant and independent predictor of PTE. Moreover, a higher neutrophil count was associated with a higher s-PESI score in COVID-19 patients developing PTE. Conclusions: Among haematological indices, NLR and more precisely PLR are cost-effective and simply calculable markers that can assist physicians in determining whether or not COVID-19 patients with clinically probable PTE require CT angiography and the higher neutrophil count can be employed as an indicator of PTE severity in COVID-19 patients. Further large multicenter and prospective studies are warranted to corroborate these observations.
29 Mar 2023Submitted to Immunity, Inflammation and Disease
31 Mar 2023Submission Checks Completed
31 Mar 2023Assigned to Editor
04 Apr 2023Review(s) Completed, Editorial Evaluation Pending
13 Apr 2023Reviewer(s) Assigned
25 Jun 2023Editorial Decision: Revise Minor
24 Jul 20231st Revision Received
07 Aug 2023Submission Checks Completed
07 Aug 2023Assigned to Editor
07 Aug 2023Review(s) Completed, Editorial Evaluation Pending
07 Aug 2023Reviewer(s) Assigned
31 Aug 2023Editorial Decision: Accept
Sep 2023Published in Immunity, Inflammation and Disease volume 11 issue 9. https://doi.org/10.1002/iid3.1012