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Prevalence and bidirectional association between rhinitis and urticaria: A systematic review and meta-analysis
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  • Peng Yongjun,
  • Shuying Xu,
  • Siming Ni,
  • Chunli Zeng
Peng Yongjun
Affiliated Hospital of Nanjing University of Chinese Medicine

Corresponding Author:pengyongjun2004@126.com

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Shuying Xu
Affiliated Hospital of Nanjing University of Chinese Medicine
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Siming Ni
Affiliated Hospital of Nanjing University of Chinese Medicine
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Chunli Zeng
Affiliated Hospital of Nanjing University of Chinese Medicine
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Abstract

Background: Rhinitis, allergic rhinitis in particular, and urticaria are both common atopic problems globally. However, there is controversy regarding the correlation between rhinits and urticaria. Objectives: To examine the accurate association between rhinitis and urticaria. Methods: Three medical databases (PubMed, Embase, and Web of Science) were searched from database inception until January 11, 2022. The prevalence and association between rhinitis and urticaria were estimated by meta-analysis. The Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines were followed, and quality assessment was performed using the Newcastle–Ottawa Scale. Pooled odds ratios (OR) with 95% confidence intervals (95% CI) and pooled prevalence were calculated using random-effects models. Results: Urticaria prevalence in patients with rhinitis was 17.6% (95% CI, 13.2%–21.9%). The pooled prevalence of rhinitis was 31.3% (95% CI, 24.2%–38.4%) in patients with urticaria, and rhinitis prevalence in patients with acute urticaria and chronic urticaria was 31.6% (95% CI, 7.4%–55.8%) and 28.7% (95% CI, 20.4%–36.9%), respectively. Rhinitis occurence was significantly associated with urticaria (OR, 2.67; 95% CI, 2.625–2.715). Limitations: Urticaria and rhinitis were diagnosed based on different criteria possibly resulting in a potential misclassification of these two diseases. Conclusion: Rhinitis and urticaria were significantly correlated. Physicians should be cognizant regarding this relationship and address nasal or skin symptoms in patients.
21 Nov 2022Submitted to Immunity, Inflammation and Disease
06 Jan 2023Submission Checks Completed
06 Jan 2023Assigned to Editor
06 Jan 2023Review(s) Completed, Editorial Evaluation Pending
12 Jan 2023Reviewer(s) Assigned
11 Apr 2023Editorial Decision: Revise Minor
14 Apr 20231st Revision Received
18 Apr 2023Submission Checks Completed
18 Apr 2023Assigned to Editor
18 Apr 2023Review(s) Completed, Editorial Evaluation Pending
23 Apr 2023Reviewer(s) Assigned
24 Apr 2023Editorial Decision: Accept