Background: Parkinson’s disease (PD) is a pervasive neurodegenerative disorder that significantly impacts the quality of life of affected individuals. Current treatment options such as pharmacological interventions and deep brain stimulation have notable limitations in their efficacy and are linked with various side effects. This review aims to examine the potential of innovative cranial nerve stimulation and neuromodulation techniques for treating PD. Methods: A comprehensive literature search was conducted using relevant keywords across major databases to identify recent advancements in cranial nerve stimulation devices, stimulation protocols, and their clinical applications for PD. The process aimed to collate information on emerging technologies, including non-invasive and minimally invasive devices, offering more targeted and personalized treatment approaches. Results: The review highlights innovative devices and stimulation protocols showing potential in PD treatment. The safety and efficacy of these techniques were compared with conventional treatments based on results from clinical trials. We analyzed the advantages and limitations of these next-generation cranial nerve stimulation and neuromodulation techniques, with a special focus on their potential to improve patient outcomes and enhance quality of life. Conclusion: Next-generation cranial nerve stimulation and neuromodulation techniques hold substantial promise for more effective and better-tolerated PD treatments. These innovative strategies potentially pave the way for novel clinical applications and improved patient care. The review also discusses translational challenges and suggests future research directions to maximize the therapeutic potential of these promising techniques in PD treatment.