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Time To Be Blunt: Substance Use In Cystic Fibrosis
  • +7
  • Sanaz Vaziri,
  • Meghan McGarry,
  • Chiung-Yu Huang,
  • Addison A. Cuneo,
  • Shaina Willwn,
  • Kensho Iwanaga,
  • Fatima Neemuchwala,
  • Elizabeth Gibb,
  • M. Chan,
  • Ngoc Ly
Sanaz Vaziri
University of California San Francisco Department of Pediatrics

Corresponding Author:sanaz.vaziri@ucsf.edu

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Meghan McGarry
University of California San Francisco Department of Pediatrics
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Chiung-Yu Huang
University of California San Francisco Department of Epidemiology and Biostatistics
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Addison A. Cuneo
University of California San Francisco Department of Pediatrics
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Shaina Willwn
University of California Davis Department of Pediatrics
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Kensho Iwanaga
University of California San Francisco Department of Pediatrics
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Fatima Neemuchwala
University of California San Francisco Department of Pediatrics
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Elizabeth Gibb
University of California San Francisco Department of Pediatrics
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M. Chan
Kaiser Permanente
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Ngoc Ly
University of California San Francisco Department of Pediatrics
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Abstract

Background: As the population of people with CF (pwCF) continues to age, attention is shifting towards addressing the unique challenges teenagers and adults face, including substance use. Changing attitudes and legality regarding marijuana and CBD may influence their use among pwCF, but data on their prevalence, reasons for use, and administration methods are lacking. Objective: Investigate marijuana, cannabidiol (CBD), e-cigarette, and cigarette usage among pwCF and explore differences in demographics, disease severity, and CFTR modulator use between current and non-users. Methods: This cross-sectional study used a one-time electronic survey to assess marijuana, CBD, e-cigarette, and cigarette use in pwCF aged >13 years. Demographic and clinical characteristics were compared between current users and non-users. The association between current substance use and CFTR modulator use was analyzed using logistic regressions. Results: Among 226 participants, 29% used marijuana, 22% used CBD, 27% used e-cigarettes, and 22% used cigarettes. Current users of all substances were more likely to be college-educated, Black, or aged 29-39 years than non-users. Current e-cigarette users were 2.9 times more likely to use CFTR modulators (95% CI 0.98-11.00, p=0.08) and current marijuana users were 2.5 times more likely to use CFTR modulators compared to non-users, adjusted for confounders. Current users of CBD, e-cigarettes, and cigarettes were more likely to have an abnormal mental health screen compared to non-users. A high proportion of never-users of marijuana and CBD expressed interest in using. Conclusion: Substance use is more prevalent among pwCF than previously reported and needs to be addressed by healthcare providers.
19 Sep 2023Submitted to Pediatric Pulmonology
19 Sep 2023Submission Checks Completed
19 Sep 2023Assigned to Editor
19 Sep 2023Review(s) Completed, Editorial Evaluation Pending
02 Oct 2023Reviewer(s) Assigned
01 Nov 2023Editorial Decision: Revise Major