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The regulatory role of autophagy between TAMs and tumor cells
  • +1
  • Min Hu,
  • Jiao-Xiu Fan,
  • Zi-Yue He,
  • Jun Zeng
Min Hu
Chongqing Normal University
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Jiao-Xiu Fan
Chongqing Normal University
Author Profile
Zi-Yue He
Chongqing Normal University
Author Profile
Jun Zeng
Chongqing Normal University

Corresponding Author:zengjun_2012@163.com

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Abstract

Cancer has become a global public health problem and its harmful effects have received widespread attention. Conventional treatments such as surgical resection, radiotherapy and other techniques are applicable to clinical practice, but new drugs are constantly being developed and other therapeutic approaches such as immunotherapy are being applied. In addition to studying the effects on individual tumor cells, it is important to explore the role of tumor microenvironment (TME) on tumor cell development since tumor cells do not exist alone but in the tumor microenvironment. In the TME, tumor cells are interconnected with other stromal cells and influence each other, among which tumor-associated macrophages (TAMs) are the most numerous immune cells. At the same time, it was found that cancer cells have different levels of autophagy from normal cells. In cancer therapy, the occurrence of autophagy plays an important role in promoting tumor cell death or inhibiting tumor cell death, and is closely related to the environment. Therefore, elucidating the regulatory role of autophagy between TAMs and tumor cells is an important breakthrough, providing new perspectives for further research on anti-tumor immune mechanisms and understanding the efficacy of cancer immunotherapy.
11 Sep 2023Submitted to Cell Biochemistry & Function
11 Sep 2023Submission Checks Completed
11 Sep 2023Assigned to Editor
11 Sep 2023Review(s) Completed, Editorial Evaluation Pending
12 Sep 2023Reviewer(s) Assigned
31 Oct 2023Editorial Decision: Revise Major
31 Jan 2024Review(s) Completed, Editorial Evaluation Pending
31 Jan 2024Editorial Decision: Revise Minor
24 Feb 20242nd Revision Received
24 Feb 2024Review(s) Completed, Editorial Evaluation Pending
04 Mar 2024Editorial Decision: Revise Minor
06 Mar 20243rd Revision Received
06 Mar 2024Review(s) Completed, Editorial Evaluation Pending
06 Mar 2024Editorial Decision: Accept