Since a magic “polypill” – the “Environment-Sleep-Emotion-Exercise-Diet” intervention [E(e)SEEDi] was discovered in 2018, it plays a pivotal role in control and prevention of human disease due to improvement of immunity by healthy lifestyle. It can be said that it is applicable, as long as one is a human and survival. However, do plants also need the magic “polypill”? When plants need a suitable environment, rational internal exercise, and balancing nutrients (fertilizers, herbicides, nutrients, pesticides, and others), do they also need sleep? And have also emotions like humans? These are interesting questions. Currently, obvious climate change threats herbal cultivation in both China and the globe, in particular the pandemic and post-COVID-19 era. Only when we understand and confirm that plants also need sleep and have emotions, can we better protect medicinal plants and promote herb cultivation and healthy growth, since traditional Chinese herbs have a good efficacy in combating cardiovascular disease.