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Trace detection of canine distemper virus based on Michelson-interferometer sensing probe
  • Wenlin Feng,
  • Xinyu Zhang,
  • Xiangyu Hou
Wenlin Feng
Chongqing University of Technology

Corresponding Author:wenlinfeng@126.com

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Xinyu Zhang
Chongqing University of Technology
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Xiangyu Hou
Chongqing University of Technology
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Abstract

A single-mode-fiber (SMF)-multimode-fiber (MMF)-tri-core-fiber (TCF) Michelson probe structure is proposed for trace detection of canine distemper virus (CDV). One end of the TCF is cut flat and fused with the multimode fiber, and the other end is coated with a silver film to enhance the reflection, and an optic-fiber sensing probe with SMF-MMF-TCF structure is obtained. The (PDDA/PSS) 3 multilayer film is modified on the surface of the fiber by layer-by-layer self-assembly method as a polyelectrolyte binder to immobilize CDV antibodies to form a (PDDA/PSS) 3/CDV antibody composite membrane for specific detection of CDV antigens. The response-recovery test of the sensor is performed to verify its repeatability. The detection limit, the sensitivity, and the linear fitting degree for CDV antigen are 0.1236 pg/ml, 1.1776 dB/(pg/ml), and 0.9899, respectively. At the same time, the stability, selectivity, and clinical samples of the sensors were also verified.
16 Aug 2023Submitted to Journal of Biophotonics
17 Aug 2023Submission Checks Completed
17 Aug 2023Assigned to Editor
17 Aug 2023Review(s) Completed, Editorial Evaluation Pending
17 Aug 2023Reviewer(s) Assigned
05 Sep 2023Editorial Decision: Revise Minor
11 Sep 20231st Revision Received
11 Sep 2023Submission Checks Completed
11 Sep 2023Assigned to Editor
11 Sep 2023Reviewer(s) Assigned
11 Sep 2023Review(s) Completed, Editorial Evaluation Pending
11 Sep 2023Editorial Decision: Accept