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Super-resolution fluorescence microscopy for investigating bacterial macromolecular complexes
  • Alexander Carsten,
  • Manuel Wolters,
  • Martin Aepfelbacher
Alexander Carsten
Universitatsklinikum Hamburg-Eppendorf Institut fur Medizinische Mikrobiologie Virologie und Hygiene
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Manuel Wolters
Universitatsklinikum Hamburg-Eppendorf Institut fur Medizinische Mikrobiologie Virologie und Hygiene
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Martin Aepfelbacher
Universitatsklinikum Hamburg-Eppendorf Institut fur Medizinische Mikrobiologie Virologie und Hygiene

Corresponding Author:m.aepfelbacher@uke.de

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Abstract

Super-resolution fluorescence microscopy techniques developed over the past two decades have pushed the resolution limit for fluorescently labeled molecules into the nanometer range. These techniques have the potential to study bacterial macromolecular complexes such as secretion systems with single-molecule resolution on a millisecond time scale. Here we review recent applications of super-resolution fluorescence microscopy in molecular bacteriology with a focus on bacterial secretion systems. We also describe MINFLUX fluorescence nanoscopy, a relatively new technique that promises to one day produce molecular movies of bacterial molecular machines in action.
04 Aug 2023Submitted to Molecular Microbiology
05 Aug 2023Submission Checks Completed
05 Aug 2023Assigned to Editor
16 Aug 2023Reviewer(s) Assigned
11 Sep 2023Review(s) Completed, Editorial Evaluation Pending
11 Sep 2023Editorial Decision: Revise Minor
11 Nov 20231st Revision Received
15 Nov 2023Submission Checks Completed
15 Nov 2023Assigned to Editor
16 Nov 2023Review(s) Completed, Editorial Evaluation Pending
16 Nov 2023Editorial Decision: Accept