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Stimuli-responsive linkers and their application in molecular imaging
  • +2
  • Jing Wang,
  • Meng Liu,
  • Xinyue Zhang,
  • Menghua Xiong,
  • Dong Luo
Jing Wang
South China University of Technology
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Meng Liu
South China University of Technology
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Xinyue Zhang
South China University of Technology
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Menghua Xiong
South China University of Technology
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Dong Luo
South China University of Technology

Corresponding Author:luodong09@scut.edu.cn

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Abstract

Molecular imaging is a non-invasive imaging method that is widely used for visualization and detection of biological events at cellular or molecular levels. Stimuli-responsive linkers that can be selectively cleaved by specific biomarkers at desired sites to release or activate imaging agents are appealing tools to improve the specificity, sensitivity, and efficacy of molecular imaging. This review summarizes the recent advances of stimuli-responsive linkers and their application in molecular imaging, highlighting the potential of these linkers in the design of activatable molecular imaging probes. We hope that this review could inspire more research interests in the development of responsive linkers and associated imaging applications.
30 Jun 2023Submitted to Exploration
08 Jul 2023Submission Checks Completed
08 Jul 2023Assigned to Editor
08 Jul 2023Reviewer(s) Assigned
18 Jul 2023Review(s) Completed, Editorial Evaluation Pending
08 Aug 2023Editorial Decision: Revise Major
23 Aug 20231st Revision Received
30 Aug 2023Submission Checks Completed
30 Aug 2023Assigned to Editor
31 Aug 2023Reviewer(s) Assigned
06 Sep 2023Review(s) Completed, Editorial Evaluation Pending
16 Oct 2023Editorial Decision: Accept