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Cognitive impairment is evident in ‘non-user’ first-degree relatives of persons with cannabis dependence syndrome: An endophenotype study.
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  • Shrayasi Das,
  • Lokesh Singh,
  • Sai Tikka,
  • Mamidipali Spoorthy,
  • Sucharita Mandal,
  • Puneet Soni,
  • Neethu Nandan
Shrayasi Das
All India Institute of Medical Sciences - Raipur
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Lokesh Singh
All India Institute of Medical Sciences - Raipur

Corresponding Author:singhlokesh123@gmail.com

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Sai Tikka
All India Institute of Medical Sciences - Bibinagar
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Mamidipali Spoorthy
Jawaharlal Nehru Medical College
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Sucharita Mandal
All India Institute of Medical Sciences - Kalyani
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Puneet Soni
All India Institute of Medical Sciences - Jodhpur
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Neethu Nandan
All India Institute of Medical Sciences - Raipur
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Abstract

Introduction- Cannabis use disorders are global emerging problem nowadays, with high prevalence and morbidity. Though cognitive impairments are one of the most replicated findings in individuals with cannabis dependence, but there are very few studies assessed cognitive functioning as a risk factor for cannabis use disorder. In this study, we assessed cognitive functioning as an endophenotype in cannabis use disorders. Methodology- In this study comparison of cognitive functioning was done among three groups- patients with cannabis dependence syndrome, their first degree relative (FDR) and normal healthy controls (HC). Each group included 30 participants. Individuals of all three groups were assessed in domains of complex attention, executive functions, language, learning and memory and perceptual-motor. Results- Performance of patients with cannabis dependence was impaired in attention, verbal memory, executive functions compared to both other groups. Attention, semantic verbal fluency and memory were found to be an endophenotype as both patient and FDR group performed poorly than HC group. Verbal memory was impaired in patients’ group compared to group of first-degree relatives, whose performance in-turn impaired than normal healthy controls. Performances of verbal and visual memory were correlated positively with age of onset and negatively with frequency of cannabis intake. Age of first-degree relatives was inversely correlated with verbal memory. Conclusion- Performance of individuals with cannabis dependence was impaired than normal healthy controls in all domains of cognitive functioning. As per definition, verbal memory could be considered as an endophenotype marker in cannabis use disorders.
28 Jul 20231st Revision Received
29 Jul 2023Submission Checks Completed
29 Jul 2023Assigned to Editor
29 Jul 2023Review(s) Completed, Editorial Evaluation Pending
29 Jul 2023Reviewer(s) Assigned
25 Aug 2023Editorial Decision: Revise Minor
26 Aug 20232nd Revision Received
28 Aug 2023Submission Checks Completed
28 Aug 2023Assigned to Editor
28 Aug 2023Review(s) Completed, Editorial Evaluation Pending
09 Sep 2023Editorial Decision: Accept