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Advances in Biosynthesis of Peptide Drugs: Technology and Industrialization
  • +3
  • Jing Wang,
  • Long Chen,
  • Song Qin,
  • Mingyuan Xie,
  • Shizhong Luo,
  • Wenjun Li
Jing Wang
Yantai Institute of Coastal Zone Research
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Long Chen
Beijing University of Chemical Technology
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Song Qin
Yantai Institute of Coastal Zone Research
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Mingyuan Xie
Sun Yat-Sen University
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Shizhong Luo
Beijing University of Chemical Technology
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Wenjun Li
Yantai Institute of Coastal Zone Research

Corresponding Author:wjli@yic.ac.cn

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Abstract

Peptide drugs are developed from endogenous or synthetic peptides with specific biological activities. They have advantages of strong target specificity, high efficacy and low toxicity, thus showing great promise in the treatment of many diseases such as cancer, infections and diabetes. Although an increasing number of peptide drugs have entered market in recent years, the preparation of peptide drug substances is yet a bottleneck problem for their industrial production. Comparing to the chemical synthesis method, peptide biosynthesis has advantages of simple synthesis, low cost, and low contamination. Therefore, the biosynthesis technology of peptide drugs has been widely used for manufacturing. Herein, we reviewed the development of peptide drugs and recent advances in peptide biosynthesis technology, in order to shed a light to the prospect of industrial production of peptide drugs based on biosynthesis technology.
31 May 2023Submitted to Biotechnology Journal
31 May 2023Submission Checks Completed
31 May 2023Assigned to Editor
01 Jun 2023Reviewer(s) Assigned
13 Jul 2023Review(s) Completed, Editorial Evaluation Pending
13 Jul 2023Editorial Decision: Revise Major
24 Jul 20231st Revision Received
24 Jul 2023Submission Checks Completed
24 Jul 2023Assigned to Editor
24 Jul 2023Reviewer(s) Assigned
06 Oct 2023Review(s) Completed, Editorial Evaluation Pending
09 Oct 2023Editorial Decision: Accept