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A Versatile, Electrophilic Reagent for Monofluoromethylthiola-tion
  • Rui Wang,
  • Long Lv,
  • Qilong Shen
Rui Wang
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
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Long Lv
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
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Qilong Shen
Shanghai Institute of Organic Chemsitry

Corresponding Author:shenql@mail.sioc.ac.cn

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Abstract

A new electrophilic monofluoromethylthiolating reagent N-fluoromethylthiophthalimide PhthSCH2F 1 was developed. Reagent 1 could be readily synthesized from easily available starting materials benzyl mercaptan and CH2FCl in three steps. N-fluoromethylthiophthalimide 1 is a powerful electrophilic monofluoromethylthiolating reagent that allows the monofluorome-thylthiolation of a wide range of nucleophiles including alkynes, aryl/vinyl boronic acids, electron-rich heteroarenes,-ketoesters and oxindoles, as well as thiols under mild conditions.
05 May 20231st Revision Received
05 May 2023Submission Checks Completed
05 May 2023Assigned to Editor
05 May 2023Review(s) Completed, Editorial Evaluation Pending
08 May 2023Reviewer(s) Assigned
09 May 2023Editorial Decision: Accept