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A New Perspective on Hippocampal Synaptic Plasticity and Post-stroke Depression
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  • Ning Sun,
  • Wen-Qiang Cui,
  • Xiao-Man Min,
  • Guang-Ming Zhang,
  • Jia-Zheng Liu,
  • Hong-Yun Wu
Ning Sun
Shandong University of Traditional Chinese Medicine
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Wen-Qiang Cui
Shandong University of Traditional Chinese Medicine Affiliated Hospital
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Xiao-Man Min
Shandong University of Traditional Chinese Medicine
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Guang-Ming Zhang
Shandong University of Traditional Chinese Medicine
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Jia-Zheng Liu
Shandong University of Traditional Chinese Medicine
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Hong-Yun Wu
Shandong University of Traditional Chinese Medicine Affiliated Hospital

Corresponding Author:whylzhangonly@126.com

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Abstract

Post-stroke depression (PSD), a common complication after stroke, severely affects the recovery and quality of life of patients with stroke. Owing to its complex mechanisms, PSD treatment remains highly challenging. Hippocampal synaptic plasticity is one of the key factors leading to PSD; however, the precise molecular mechanisms remain unclear. Numerous studies have found that neurotrophic factors, protein kinases, and neurotransmitters influence depressive behavior by modulating hippocampal synaptic plasticity. This review further elaborates on the role of hippocampal synaptic plasticity in PSD by summarizing recent research and analyzing possible molecular mechanisms. Evidence for the correlation between hippocampal mechanisms and PSD helps to better understand the pathological process of PSD and improve its treatment.
11 Apr 2023Submitted to European Journal of Neuroscience
12 Apr 2023Submission Checks Completed
12 Apr 2023Assigned to Editor
14 Apr 2023Review(s) Completed, Editorial Evaluation Pending
17 Apr 2023Reviewer(s) Assigned
04 Jun 2023Editorial Decision: Revise Minor
01 Jul 20231st Revision Received
01 Jul 2023Submission Checks Completed
01 Jul 2023Assigned to Editor
01 Jul 2023Review(s) Completed, Editorial Evaluation Pending
03 Jul 2023Editorial Decision: Accept