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SARS-CoV-2 infection in children with Cystic Fibrosis: A Cross-sectional Multicenter Study in Spain. New waves, new knowledge.
  • +33
  • Pedro Mondejar-López,
  • Laura Moreno-Galarraga,
  • Cristina De Manuel,
  • Enrique Blitz Castro,
  • Maynor Bravo-Lopez,
  • Silvia Gartner,
  • Estela Pérez-Ruiz,
  • Pilar Caro-Aguilera,
  • Veronica Sanz Santiago ,
  • Alejandro López-Neyra,
  • Maria Luna-Paredes,
  • Miguel Garcia Gonzalez,
  • Jordi Costa,
  • Maria Cols-Roig,
  • Isabel Delgado-Pecellín,
  • Silvia Castillo-Corullón,
  • Marta Ruiz de Valbuena,
  • Patricia W. García-Marcos,
  • Antonio Aguilar Fernandez,
  • Carlos Martín,
  • Mª Verisima Barajas Sanchez,
  • Orlando Mesa Medina,
  • Cati Bover-Bauza,
  • Joan Figuerola Mulet,
  • Belén García Avilés,
  • Mª Jesus Rodriguez Saez,
  • Carlos Garcia-Magan,
  • Patricia Juarez Marruecos,
  • Jose Ramon Gutierrez-Martinez,
  • Isidoro Cortell-Aznar,
  • David Gomez-Pastrana,
  • M. Valle Velasco Gonzalez,
  • M. Isabel Barrio,
  • Manuel Sanchez-Solis,
  • Óscar Asensio de la Cruz,
  • Maria Dolores Pastor-Vivero
Pedro Mondejar-López
Hospital Clinico Universitario Virgen de la Arrixaca

Corresponding Author:mondejarp@gmail.com

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Laura Moreno-Galarraga
Instituto de Investigacion Sanitaria de Navarra
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Cristina De Manuel
Fundacion para la Investigacion e Innovacion Biomedica de Atencion Primaria de la Comunidad de Madrid
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Enrique Blitz Castro
Instituto Ramon y Cajal de Investigacion Sanitaria
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Maynor Bravo-Lopez
Hospital Universitari Vall d'Hebron Servei de Medicina Interna
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Silvia Gartner
Hospital Universitari Vall d'Hebron Servei de Medicina Interna
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Estela Pérez-Ruiz
Hospital Regional Universitario de Malaga
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Pilar Caro-Aguilera
Hospital Regional Universitario de Malaga
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Veronica Sanz Santiago
Hospital Infantil Universitario Nino Jesus
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Alejandro López-Neyra
Hospital Infantil Universitario Nino Jesus
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Maria Luna-Paredes
Hospital Universitario 12 de Octubre
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Miguel Garcia Gonzalez
Consorcio Corporacion Sanitaria Parc Tauli
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Jordi Costa
Hospital Sant Joan de Deu
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Maria Cols-Roig
Hospital Sant Joan de Deu
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Isabel Delgado-Pecellín
Centro de Investigacion Biomedica en Red Enfermedades Respiratorias
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Silvia Castillo-Corullón
Hospital Clinico Universitario
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Marta Ruiz de Valbuena
Fundacion para la Investigacion e Innovacion Biomedica de Atencion Primaria de la Comunidad de Madrid
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Patricia W. García-Marcos
Hospital Clinico Universitario Virgen de la Arrixaca
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Antonio Aguilar Fernandez
Hospital Universitario Materno Infantil de Canarias
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Carlos Martín
Hospital Universitario Miguel Servet
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Mª Verisima Barajas Sanchez
Hospital Clinico de Salamanca
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Orlando Mesa Medina
Hospital Universitario Nuestra Senora de la Candelaria
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Cati Bover-Bauza
Hospital Universitari Son Espases Servei de Cirurgia Pediatrica
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Joan Figuerola Mulet
Hospital Universitari Son Espases Servei de Cirurgia Pediatrica
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Belén García Avilés
Hospital Universitari Sant Joan d'Alacant
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Mª Jesus Rodriguez Saez
Hospital Alvaro Cunqueiro
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Carlos Garcia-Magan
Hospital Clinico Universitario de Santiago de Compostela Servicio de Cardiologia
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Patricia Juarez Marruecos
Complejo Hospitalario Torrecardenas
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Jose Ramon Gutierrez-Martinez
Hospital Universitario Central de Asturias
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Isidoro Cortell-Aznar
Hospital Universitari i Politecnic La Fe Biblioteca
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David Gomez-Pastrana
Hospital Universitario de Jerez de la Frontera
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M. Valle Velasco Gonzalez
Hospital Universitario de Canarias
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M. Isabel Barrio
Fundacion para la Investigacion e Innovacion Biomedica de Atencion Primaria de la Comunidad de Madrid
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Manuel Sanchez-Solis
Hospital Clinico Universitario Virgen de la Arrixaca
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Óscar Asensio de la Cruz
Consorcio Corporacion Sanitaria Parc Tauli
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Maria Dolores Pastor-Vivero
Instituto de Investigacion Sanitaria Biocruces Bizkaia
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Abstract

Introduction Viral infections are associated with pulmonary exacerbations in children with Cystic Fibrosis (cwCF), but after 3 years of SARS-CoV-2 pandemic, whether cwCF are at higher risk of developing COVID-19 or its adverse consequences remains controversial. Methods We conducted an observational, multicenter, cross-sectional study of cwCF infected by SARS-CoV-2 between March 2020 and June 2022, (1 st to 6 th COVID-19 pandemic waves) in Spain. The study aimed to describe patients’ basal characteristics, SARS-CoV-2 clinical manifestations and outcomes, and whether there were differences across the pandemic waves. Results During study time, 351 SARS-CoV2 infections were reported among 341 cwCF. Median age was 8.5 years (range 0-17) and 51% were female. Cases were unevenly distributed across the pandemic, with most cases (82%) clustered between November 2021 and June 2022 (6 th wave, also known as Omicron Wave due to the higher prevalence of this strain in that period in Spain). Most cwCF were asymptomatic (24.8%) or presented with mild Covid-19 symptoms (72.9%). Among symptomatic, most prevalent symptoms were fever (62%) and increased cough (53%). No multisystem inflammatory syndrome (MIS-C), persisting symptoms, long-term sequelae or deaths were reported. Conclusions Spanish current data indicate that cwCF do not experience higher risks of SARS-CoV-2 infection nor worse health outcomes or sequelae. Changes in patients’ basal characteristics, clinical courses and outcomes were detected across waves. While the pandemic continues, and new SARS-CoV-2 variants are being identified, a worldwide monitoring of COVID-19 in pediatric CF patients is needed.
09 Apr 2023Submitted to Pediatric Pulmonology
11 Apr 2023Submission Checks Completed
11 Apr 2023Assigned to Editor
11 Apr 2023Review(s) Completed, Editorial Evaluation Pending
28 Apr 2023Reviewer(s) Assigned
03 Jun 2023Editorial Decision: Revise Major
17 Jul 20231st Revision Received
17 Jul 2023Review(s) Completed, Editorial Evaluation Pending
17 Jul 2023Submission Checks Completed
17 Jul 2023Assigned to Editor
17 Jul 2023Reviewer(s) Assigned
11 Aug 2023Editorial Decision: Accept