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A Case of Acute Pulmonary Complication due to Botulinum Toxin: Patient with Central Pontine Myelinolysis Developed Acute Respiratory Distress Syndrome after Botulinum Neurotoxin Type A Injection Into Spastic Lower Extremity Muscles
  • Hasan Hüseyin Gökpınar,
  • Furkan Ertürk Urfalı
Hasan Hüseyin Gökpınar
Kütahya Health Sciences University

Corresponding Author:hasanhuseyin.gokpinar@ksbu.edu.tr

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Furkan Ertürk Urfalı
Kütahya Health Sciences University
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Abstract

Purpose Chemodenervation with botulinum neurotoxin type A (BoNTA) is the preferred method for focal spasticity management among various treatment options. While BoNTA injection is considered safe, its widespread use and increasing evidence raise safety concerns. Case In this paper, we present a patient with central pontine myelinolysis, a rare disease, who developed Acute Respiratory Distress Syndrome (ARDS) on the third day after BoNTA application to the spastic gastrocnemius muscle group and required intubation in the intensive care unit due to this complication. Conclusion To our knowledge, this is the first case reported in the literature to develop an acute pulmonary complication after BoNTA injection into spastic lower extremity muscles.
27 Mar 2023Submitted to British Journal of Clinical Pharmacology
03 Apr 2023Submission Checks Completed
03 Apr 2023Assigned to Editor
03 Apr 2023Review(s) Completed, Editorial Evaluation Pending
06 May 2023Reviewer(s) Assigned
24 May 2023Editorial Decision: Revise Major
09 Jul 20231st Revision Received
10 Jul 2023Submission Checks Completed
10 Jul 2023Assigned to Editor
10 Jul 2023Review(s) Completed, Editorial Evaluation Pending
11 Jul 2023Reviewer(s) Assigned
05 Aug 2023Editorial Decision: Accept