Objective: Interpersonal difficulties are salient among those with a history of NSSI and precede NSSI urges and behaviors. Yet, limited research has focused on identifying which aspects of interpersonal stress may confer risk for NSSI. Method: The current study aimed to leverage data from two samples (combined n=206; n=114 with NSSI history) of participant-driven interviews regarding a recent interpersonal stressor to enhance the field’s knowledge of interpersonal difficulties in relation to NSSI risk. Results: Using topic modeling to extract thematic information, analyses identified four main topics: daily difficulties; family members; adjectives/verbal fillers; and friendship/romantic relationships. Relationships between the topics and three predictors (i.e., NSSI history, emotion dysregulation, sample) were examined. In one sample, the proportion of ‘adjectives/verbal fillers’ was greater for participants with a NSSI history and at higher levels of emotion dysregulation. Across samples, for participants with a NSSI history, ‘adjectives/verbal fillers’ and ‘friendship/romantic partners’ increased with levels of emotion dysregulation. Conclusion: Findings highlight a greater use of adjectives and verbal fillers among individuals with a history of NSSI and higher levels of emotion dysregulation. This pattern of language may serve as an indicator of a specific aspect of emotion regulation difficulties that confers risk for NSSI.